SCHEMBL28027503

SCHEMBL28027503

N#CC1=C(N(N)C(N)=O)SC(N(N)C(N)=O)=C(C#N)C1c1ccccc1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CUL4A Q13619 1/20 0.59
EEF2K O00418 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28026890 0.84 EEF2K (0.56) CUL4AEEF2K
SCHEMBL28026886 0.78 CUL4A (0.51) CUL4A
SCHEMBL15571207 0.74 CUL4A (1.00) CUL4AEEF2K
SCHEMBL28027509 0.74 CUL4A (0.55) CUL4AEEF2K
SCHEMBL28027554 0.73 MAPT (0.61) CUL4A
SCHEMBL28026889 0.73 CUL4A (0.54) CUL4A
SCHEMBL28026888 0.72 KMT2A (0.43) CUL4A
SCHEMBL28026887 0.70 KMT2A (0.40) CUL4A
SCHEMBL28027514 0.70 CUL4A (0.54) CUL4A
SCHEMBL28027511 0.69 ALDH1A1 (0.58) CUL4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104968323-A Inhibitors of CRL4 ubiquitin ligase and uses thereof UNIV CORNELL 2015-10-07 CN claimed
CN-104968323-A Inhibitors of CRL4 ubiquitin ligase and uses thereof UNIV CORNELL 2015-10-07 CN disclosed