Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.38 |
| ▸ | MEN1 | O00255 | 9/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28026887 | 0.86 | KMT2A (0.40) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28026886 | 0.86 | CUL4A (0.51) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28026888 | 0.85 | KMT2A (0.43) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28027514 | 0.83 | CUL4A (0.54) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28026892 | 0.83 | CUL4A (0.48) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28027509 | 0.80 | CUL4A (0.55) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28026890 | 0.78 | EEF2K (0.56) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28027503 | 0.73 | CUL4A (0.59) | CUL4A | |
| SCHEMBL15571642 | 0.71 | CUL4A (1.00) | CUL4AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28027511 | 0.69 | ALDH1A1 (0.58) | CUL4AALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | claimed |
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | disclosed |