Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CUL4A | Q13619 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28027509 | 0.85 | CUL4A (0.55) | EEF2KMAPTGAAGFERCACNA1B | |
| SCHEMBL28027503 | 0.84 | CUL4A (0.59) | EEF2KCUL4A | |
| SCHEMBL28026886 | 0.81 | CUL4A (0.51) | MAPTGAACACNA1BAPBA1ALDH1A1 | |
| SCHEMBL28026889 | 0.78 | CUL4A (0.54) | MAPTGAAGFERALDH1A1KDM4E | |
| SCHEMBL28026888 | 0.78 | KMT2A (0.43) | MAPTGAACACNA1BAPBA1ALDH1A1 | |
| SCHEMBL28027554 | 0.76 | MAPT (0.61) | MAPTALDH1A1KDM4ETSHRNPC1 | |
| SCHEMBL28027514 | 0.73 | CUL4A (0.54) | MAPTGAAALDH1A1KDM4ETSHR | |
| SCHEMBL28026887 | 0.73 | KMT2A (0.40) | MAPTGAAALDH1A1KDM4ETSHR | |
| SCHEMBL15572213 | 0.72 | EEF2K (1.00) | EEF2KMAPTGAAALDH1A1KDM4E | |
| SCHEMBL28027511 | 0.72 | ALDH1A1 (0.58) | MAPTALDH1A1KDM4ETSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | claimed |
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | disclosed |