SCHEMBL28026936

SCHEMBL28026936

CC(=O)Oc1ccc2c(c1)N=CNC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.44
CA2 P00918 1/20 0.41
CA5A P35218 1/20 0.41
MAPT P10636 4/20 0.39
POLB P06746 2/20 0.39
PKM P14618 1/20 0.39
KDM4E B2RXH2 4/20 0.39
LMNA P02545 3/20 0.39
CYP3A4 P08684 2/20 0.38
GLA P06280 2/20 0.38
GAA P10253 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
ALDH1A1 P00352 1/20 0.36
OPRM1 P35372 1/20 0.36
CA12 O43570 2/20 0.36
CA9 Q16790 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL28107904 0.87 ACHE (0.43) ACHECA2CA5AMAPTPOLB
SCHEMBL10798207 0.71 ACHE (0.47) ACHECA2CA5AMAPTPOLB
SCHEMBL28413209 0.71 LCK (0.39) KDM4ESMN1; SMN2ALDH1A1
Bromide SCHEMBL9204144 0.70 ACHE (0.46) ACHECA2CA5AMAPTPOLB
Hydrochloric Acid SCHEMBL27919833 0.70 ACHE (0.46) ACHECA2CA5AMAPTPOLB
SCHEMBL27919692 0.70 ASIC3 (0.47) ACHECA2CA5A
SCHEMBL1648356 0.70 PNMT (0.53)
Hydrochloric Acid SCHEMBL27835837 0.69 PNMT (0.51)
SCHEMBL9404815 0.68 CA2 (0.47) ACHECA2CA5AMAPTPOLB
SCHEMBL31758052 0.67 PNMT (0.43) ACHEMAPTGAATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104755465-A Heterocyclic compounds TAKEDA PHARMACEUTICAL 2015-07-01 CN disclosed