Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028145 | 0.63 | CHRNB2 (0.41) | CRHBPCRHR2POLBGPR55ALDH1A1 | |
| SCHEMBL27954149 | 0.63 | ALDH1A1 (0.35) | POLBGPR55ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29531709 | 0.62 | CRHBP (0.41) | CRHBPCRHR2POLBALDH1A1MMP2 | |
| SCHEMBL27274817 | 0.61 | POLB (0.39) | POLBGPR55ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5924523 | 0.59 | ALDH1A1 (0.47) | POLBALDH1A1MMP2MMP9MEN1 | |
| SCHEMBL26342290 | 0.58 | CCR2 (0.38) | CRHBPCRHR2CCR2MEN1KMT2A | |
| SCHEMBL2640739 | 0.58 | MAPT (0.59) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23375839 | 0.57 | CCR2 (0.40) | CRHBPCRHR2CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL28806304 | 0.57 | P2RX1 (0.35) | SLC6A2SLC6A3 | |
| SCHEMBL21447355 | 0.57 | CCR2 (0.40) | CRHBPCRHR2CHRNB2SLC6A2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854108-A | Pyrrolotriazinone derivatives as pi3k inhibitors | ALMIRALL SA | 2015-08-19 | — | — | CN | claimed |
| CN-104854108-A | Pyrrolotriazinone derivatives as pi3k inhibitors | ALMIRALL SA | 2015-08-19 | — | — | CN | disclosed |