Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | IL6 | P05231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028872 | 0.78 | TLR7 (0.49) | NUDT1TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL19924572 | 0.71 | TLR7 (0.47) | NUDT1TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL23202278 | 0.70 | TLR7 (0.57) | NUDT1TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL28028891 | 0.70 | ALDH1A1 (0.44) | NUDT1TLR7KDM4EALDH1A1MAPT | |
| SCHEMBL30011499 | 0.70 | TLR7 (0.57) | NUDT1TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL30012102 | 0.70 | TRAP1 (0.69) | TLR7KDM4EALDH1A1HPGDGAA | |
| SCHEMBL23202316 | 0.70 | TRAP1 (0.69) | TLR7KDM4EALDH1A1HPGDGAA | |
| SCHEMBL28029216 | 0.69 | PIK3CD (0.49) | NUDT1TLR7MTORADORA2A | |
| SCHEMBL23392757 | 0.69 | TLR7 (0.62) | NUDT1TLR7KDM4EALDH1A1HPGD | |
| SCHEMBL30012779 | 0.69 | TLR7 (0.62) | NUDT1TLR7KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107976546-A | Inhibition of phosphorylation to TOR kinase inhibiting activities mark PRAS40, GSK3- β or P70S6K1 | 西格诺药品有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-104870998-B | inhibition of phosphorylation of PRAS40, GSK3- β or P70S6K1 as a marker of TOR kinase inhibitory activity | 西格诺药品有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-104870998-A | Inhibition of phosphorylation of PRAS40, GSK 3-beta or P70S6K1 as a marker of TOR kinase inhibitory activity | SIGNAL PHARM LLC | 2015-08-26 | — | — | CN | disclosed |