Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.49 |
| ▸ | CA1 | P00915 | 9/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 7/20 | 0.45 |
| ▸ | CA7 | P43166 | 6/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958230 | 0.79 | MAPT (0.56) | CA2CA1CA12CA9POLB | |
| SCHEMBL28862587 | 0.77 | CA1 (0.46) | CA2CA1CA12CA9POLB | |
| SCHEMBL5838871 | 0.77 | HPGD (0.52) | POLBMEN1KMT2AL3MBTL1BLM | |
| SCHEMBL7944958 | 0.73 | ALDH1A1 (0.50) | POLBMEN1KMT2AL3MBTL1BLM | |
| SCHEMBL28225354 | 0.72 | L3MBTL1 (0.61) | CA2CA1CA12CA9POLB | |
| SCHEMBL27893523 | 0.70 | DOT1L (0.52) | CA2CA1CA12CA9POLB | |
| SCHEMBL27915770 | 0.69 | CA2 (0.72) | CA2CA1CA12CA9VCAM1 | |
| SCHEMBL1958228 | 0.69 | POLB (0.48) | CA2CA1CA12CA9VCAM1 | |
| SCHEMBL29450348 | 0.68 | KMT2A (0.43) | POLBMEN1KMT2AMAPTCTDSP1 | |
| SCHEMBL1874184 | 0.68 | CYP2C9 (0.42) | CA2CA1CA12CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008322-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102947285-B | Sulfonamide derivatives as BCL-2-selective apoptosis inducers for the treatment of cancer and immune diseases | ABBVIE (US) | 2015-08-26 | — | — | CN | disclosed |