Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842551 | 0.80 | HTT (0.51) | MAPTLMNAALDH1A1HTTHSD17B10 | |
| SCHEMBL10748359 | 0.75 | MAPT (0.72) | MAPTLMNAALDH1A1HTTPKM | |
| SCHEMBL2983050 | 0.74 | ACHE (0.40) | MAPTLMNAALDH1A1HSD17B10GAA | |
| SCHEMBL28861802 | 0.74 | CTNNB1 (0.51) | LMNAHTTPKMGAAMEN1 | |
| SCHEMBL942882 | 0.73 | CYP1A2 (0.46) | MAPTLMNAALDH1A1HTTPKM | |
| SCHEMBL7642520 | 0.73 | HSD17B10 (0.46) | ALDH1A1HTTHSD17B10GAAMEN1 | |
| SCHEMBL28016848 | 0.73 | GAA (0.40) | ALDH1A1GAACYP3A4HDAC6CYP2C9 | |
| SCHEMBL6768095 | 0.72 | CYP1A2 (0.44) | MAPTLMNAALDH1A1HTTGAA | |
| Bicarbonate SCHEMBL28180169 | 0.72 | ACHE (0.38) | MAPTLMNAALDH1A1HTTGAA | |
| SCHEMBL9632083 | 0.71 | GPBAR1 (0.48) | MAPTLMNAALDH1A1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105121437-B | Coumarin derivative and method for treating cystic fibrosis, chronic obstructive pulmonary disease and misfolded protein matter illness | 发现生物医药公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105246887-B | Coumarin derivative and the method for treating hyperproliferative disease | 发现生物医药公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-105246887-A | Coumarin derivatives and methods of use in treating hyperproliferative diseases | DISCOVERYBIOMED INC | 2016-01-13 | — | — | CN | disclosed |
| CN-105121437-A | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders | DISCOVERYBIOMED INC | 2015-12-02 | — | — | CN | disclosed |