SCHEMBL7739117

SCHEMBL7739117

NC(=O)Nc1cccc(NC(=O)c2ccccc2)c1

nearest known ligand 0.82

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KCNK3 O14649 11/20 0.82
▸ KCNK9 Q9NPC2 9/20 0.82
▸ SIRT1 Q96EB6 1/20 0.72
▸ MEN1 O00255 4/20 0.68
▸ KMT2A Q03164 4/20 0.68
▸ TP53 P04637 1/20 0.68
▸ POLB P06746 1/20 0.66
▸ NPC1 O15118 2/20 0.65
▸ RAB9A P51151 2/20 0.65
▸ HPGD P15428 1/20 0.65
▸ SIRT2 Q8IXJ6 1/20 0.64
▸ ALDH1A1 P00352 1/20 0.62
▸ MAPT P10636 1/20 0.62
▸ LPAR3 Q9UBY5 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2298254 0.91 KCNK3 (1.00) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715912 0.87 KCNK3 (0.92) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715827 0.87 KCNK3 (0.92) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL28031075 0.86 KCNK3 (0.77) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL4004339 0.86 KCNK3 (0.76) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL18953533 0.85 KCNK3 (0.89) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL14715832 0.85 KCNK3 (0.88) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL22699755 0.85 KCNK3 (0.77) KCNK3KCNK9SIRT1MEN1KMT2A
SCHEMBL22699737 0.85 MEN1 (0.84) KCNK3KCNK9MEN1KMT2ATP53
SCHEMBL3690365 0.84 MAPT (0.59) KCNK3KCNK9MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200369901-A1 DISPERSION, INK JET RECORDING METHOD, RECORDED MATERIAL, AND COMPOUND FUJIFILM CORPORATION (JP) 2020-11-26 — — US disclosed
US-20020019414-A1 N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors NOVARTIS AG (CH) 2002-02-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019414-A1 N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors AXL, TYRO3, KDR KCNK3 3412/4885KCNK9 2521/4885SIRT1 1656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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