Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705441 | 0.91 | GABRA1 (0.42) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 | |
| Ammonia Solution, Strong SCHEMBL234223 | 0.89 | ESR1 (0.41) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 | |
| Dimethylamine SCHEMBL1830617 | 0.85 | ESR1 (0.38) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 | |
| SCHEMBL31616424 | 0.83 | BACE1 (0.43) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 | |
| SCHEMBL980708 | 0.79 | PRKCI (0.46) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 | |
| SCHEMBL28042783 | 0.79 | PRKCI (0.46) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL30026897 | 0.79 | TRPA1 (0.48) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL858277 | 0.79 | TRPA1 (0.48) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL7910350 | 0.78 | KLF10 (0.39) | ESR1ESR2GABRA1GABRB2BACE1 | |
| SCHEMBL7020614 | 0.78 | POLB (0.38) | ESR1ESR2HSP90AA1HSP90AB1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104911006-A | Hydraulic oil and preparation method thereof | HUANG JINTANG | 2015-09-16 | — | — | CN | disclosed |