Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716706 | 0.83 | RXFP1 (0.51) | GFERALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL6815137 | 0.75 | GFER (0.71) | GFERALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL3407364 | 0.74 | PTPN2 (0.75) | GFERKMT2AMAPTPKMSMN1; SMN2 | |
| SCHEMBL7122996 | 0.74 | ALDH1A1 (0.68) | ALDH1A1KMT2AMAPTMAPK1PKM | |
| SCHEMBL4361861 | 0.73 | PTPN1 (0.76) | ALDH1A1KDM4EGAA | |
| SCHEMBL6538622 | 0.72 | GFER (0.63) | GFERKMT2AMAPTPKMSMN1; SMN2 | |
| SCHEMBL14075179 | 0.72 | LTC4S (0.66) | GFERKMT2AMAPK1PKMCYP1A2 | |
| SCHEMBL21701478 | 0.72 | CYP1A2 (0.61) | GFERALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL6933566 | 0.72 | CYP1A2 (0.61) | GFERALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL15528812 | 0.72 | MAPK1 (0.71) | ALDH1A1KMT2AMAPTMAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | disclosed |
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |