Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | LDLR | P01130 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443366 | 0.79 | ACMSD (0.53) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28682072 | 0.77 | CA12 (0.54) | LMNAALDH1A1KDM4EPTGDR2MEN1 | |
| SCHEMBL29490978 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4EGFERMEN1KMT2A | |
| SCHEMBL20284041 | 0.74 | DEGS1 (1.00) | DEGS1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL2270561 | 0.73 | LMNA (0.68) | DEGS1LMNANQO2ALOX15MAOB | |
| SCHEMBL28033796 | 0.72 | DEGS1 (0.56) | DEGS1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL4598601 | 0.72 | KDM4E (0.45) | ALDH1A1KDM4EGFERMEN1KMT2A | |
| SCHEMBL17699117 | 0.70 | CHRNB2 (0.55) | HDAC8ALDH1A1KDM4EMEN1POLB | |
| SCHEMBL28033797 | 0.70 | DEGS1 (0.53) | DEGS1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL29655541 | 0.70 | CA12 (0.53) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954670-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062230-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX, INC. (US) | 2007-05-31 | — | — | WO | disclosed |