Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556797 | 0.86 | RIPK1 (0.42) | LMNANPC1RAB9ARIPK1SMN1; SMN2 | |
| SCHEMBL3085177 | 0.85 | NPC1 (0.48) | LMNANPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL28303312 | 0.82 | RXFP1 (0.45) | NPC1RAB9ARIPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28304517 | 0.82 | NPC1 (0.49) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL28303247 | 0.79 | CA12 (0.48) | LMNARAB9ARIPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7074490 | 0.76 | NPC1 (0.44) | LMNANPC1RAB9ACYP2C19ALDH1A1 | |
| SCHEMBL8854666 | 0.76 | CYP3A4 (0.50) | L3MBTL1CYP3A4ALDH1A1ADH1BADH1C | |
| SCHEMBL5499258 | 0.76 | HPGD (0.45) | NPC1RAB9ARIPK1SMN1; SMN2CYP3A4 | |
| SCHEMBL24501680 | 0.75 | IDO1 (0.46) | LMNARIPK1SMN1; SMN2L3MBTL1CYP3A4 | |
| SCHEMBL10650842 | 0.74 | LMNA (0.58) | LMNANPC1RAB9ARIPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109956900-A | Compound and pharmaceutical composition comprising it | 财团法人工业技术研究院 | 2019-07-02 | — | — | CN | disclosed |
| CN-104876955-B | Arginase inhibitor and its treatment use | 马尔斯公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-103068830-B | Arginase inhibitors and therapeutic uses thereof | 马尔斯公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-104876955-A | Inhibitors Of Arginase And Their Therapeutic Applications | MARS INC | 2015-09-02 | — | — | CN | disclosed |