Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | RPA1 | P27694 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728116 | 0.85 | SMPD1 (0.64) | SMN1; SMN2PTGS2MALT1NFKB1NFKB2 | |
| SCHEMBL28180312 | 0.85 | MDM2 (0.81) | BCL2MDM2MCL1SMN1; SMN2RPA1 | |
| SCHEMBL28038235 | 0.84 | SMPD1 (0.67) | SMN1; SMN2PTGS2MALT1NFKB1NFKB2 | |
| SCHEMBL13239857 | 0.81 | RPA1 (0.70) | BCL2MDM2MCL1SMN1; SMN2PTGS2 | |
| SCHEMBL9643919 | 0.81 | MALT1 (0.73) | SMN1; SMN2MALT1NFKB1NFKB2RELA | |
| SCHEMBL8369157 | 0.80 | RPA1 (0.65) | SMN1; SMN2PTGS2RPA1SMPD1PPP1CA | |
| SCHEMBL877377 | 0.80 | SMPD1 (0.58) | SMN1; SMN2PTGS2MALT1NFKB1NFKB2 | |
| SCHEMBL3863671 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2PTGS2MALT1NFKB1NFKB2 | |
| SCHEMBL28038245 | 0.78 | MDM2 (0.80) | BCL2MDM2MCL1SMN1; SMN2RPA1 | |
| SCHEMBL3866506 | 0.78 | SMN1; SMN2 (0.82) | SMN1; SMN2PTGS2MALT1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061315-A | 1, 5-diphenylpyrazole-3-carboxylic acid compounds and application thereof | UNIV DALIAN TECH | 2015-11-18 | — | — | CN | disclosed |