Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 known ✓ | Q02750 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29568960 | 0.89 | MAOA (0.58) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL382951 | 0.89 | MAOA (0.58) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL9137817 | 0.74 | MAOA (0.55) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL999481 | 0.72 | ALOX15 (0.44) | TDP1ALOX15ALDH1A1TYMS | |
| SCHEMBL23728207 | 0.72 | MAOA (0.52) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL9145106 | 0.71 | MAOA (0.47) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL9145121 | 0.71 | MAOA (0.47) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL31548711 | 0.71 | TDP1 (0.60) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL2087097 | 0.71 | TDP1 (0.60) | MAOAMAPTTDP1ALOX15ALDH1A1 | |
| SCHEMBL166198 | 0.70 | ALOX15 (0.52) | TDP1ALOX15ALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105031623-A | Biological preparation and application of same in preparation of drugs used for preventing and controlling Ebola virus | SHANXI JINBO BIOMEDICAL CO LTD | 2015-11-11 | — | — | CN | claimed |
| CN-105031623-A | Biological preparation and application of same in preparation of drugs used for preventing and controlling Ebola virus | SHANXI JINBO BIOMEDICAL CO LTD | 2015-11-11 | — | — | CN | disclosed |