SCHEMBL28038832

SCHEMBL28038832

CCCCNc1cccc(C(=O)OC(C)(C)C)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 1/20 0.42
ADRA1B P35368 1/20 0.42
RIPK1 Q13546 1/20 0.41
CNR2 P34972 4/20 0.40
TSHR P16473 1/20 0.40
HTT P42858 1/20 0.40
CNR1 P21554 1/20 0.40
KDM4E B2RXH2 1/20 0.40
GLA P06280 1/20 0.40
KDM6B O15054 1/20 0.39
KDM4C Q9H3R0 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
F2R P25116 1/20 0.38
P2RX7 Q99572 1/20 0.37
MAPK8 P45983 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28823422 0.95 CNR2 (0.44) ADRA1AADRA1BCNR2TSHRCNR1
SCHEMBL28038888 0.95 CNR2 (0.44) ADRA1AADRA1BCNR2TSHRCNR1
SCHEMBL28039144 0.95 CNR2 (0.44) ADRA1AADRA1BCNR2TSHRCNR1
SCHEMBL28039136 0.95 CNR2 (0.44) ADRA1AADRA1BCNR2TSHRCNR1
SCHEMBL31110129 0.85 NAMPT (0.44) ADRA1AADRA1BHTTKDM4EL3MBTL1
SCHEMBL31665348 0.85 NAMPT (0.44) ADRA1AADRA1BHTTKDM4EL3MBTL1
SCHEMBL23748672 0.82 KDM4E (0.52) RIPK1CNR2CNR1KDM4EGLA
SCHEMBL28038899 0.79 ADRA1A (0.42) ADRA1AADRA1BKDM4EGLAL3MBTL1
SCHEMBL23748664 0.76 CNR2 (0.50) CNR2CNR1KDM4EKDM6BKDM4C
SCHEMBL5136114 0.75 PLK1 (0.51) CNR2CNR1KDM6BKDM4CCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104981249-A Antimicrobial compounds, their synthesis and applications thereof SEC DEP FOR HEALTH 2015-10-14 CN disclosed