Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177151 | 0.82 | KARS1 (0.43) | POLBFFAR1NMT1PDK1RIPK2 | |
| SCHEMBL29129758 | 0.81 | FFAR1 (0.47) | POLBFFAR1PDK1RIPK2 | |
| SCHEMBL14412223 | 0.81 | NMT1 (0.52) | TGFBR1NMT1RIPK2 | |
| SCHEMBL12759448 | 0.77 | TGFBR1 (0.48) | TGFBR1POLBNMT1RIPK2 | |
| SCHEMBL5362756 | 0.77 | DYRK1A (0.56) | POLBFFAR1DYRK1A | |
| SCHEMBL29711750 | 0.76 | HSD17B2 (0.48) | NMT1PDK1RIPK2 | |
| SCHEMBL2616608 | 0.76 | HSD17B2 (0.48) | NMT1PDK1RIPK2 | |
| SCHEMBL17264894 | 0.76 | NMT1 (0.52) | TGFBR1NMT1RIPK2 | |
| SCHEMBL23571873 | 0.75 | F2 (0.49) | POLBNMT1DYRK1ARIPK2 | |
| SCHEMBL29644212 | 0.75 | AGXT (0.55) | TGFBR1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164125-A | 2-phenyl or 2-heteroaryl imidazo [1, 2-a ] pyridine derivatives | HOFFMANN LA ROCHE | 2015-12-16 | — | — | CN | claimed |
| CN-105164125-A | 2-phenyl or 2-heteroaryl imidazo [1, 2-a ] pyridine derivatives | HOFFMANN LA ROCHE | 2015-12-16 | — | — | CN | disclosed |