Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9664824 | 0.81 | CYP19A1 (0.50) | KDM4EL3MBTL1HPGDSIDO1CYP11B1 | |
| SCHEMBL20937641 | 0.81 | KDM4E (0.46) | KDM4EL3MBTL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL2263350 | 0.71 | CNR1 (0.48) | KDM4EL3MBTL1HPGDSCNR1ALDH1A1 | |
| SCHEMBL2825301 | 0.69 | TSHR (0.48) | KDM4EHPGDSIDO1CYP11B1CYP11B2 | |
| SCHEMBL4428277 | 0.69 | NOTUM (0.48) | KDM4EL3MBTL1CNR1ALDH1A1HPGD | |
| SCHEMBL2260831 | 0.68 | GSK3A (0.48) | KDM4EHPGDSIDO1CYP11B1CYP11B2 | |
| SCHEMBL2261486 | 0.68 | KDM4E (0.71) | KDM4EL3MBTL1CNR1ALDH1A1HPGD | |
| SCHEMBL20853006 | 0.68 | CCR2 (0.54) | KDM4EL3MBTL1ALDH1A1HPGDKMT2A | |
| SCHEMBL28035380 | 0.66 | HDAC8 (0.47) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10430575 | 0.64 | KMT2A (0.49) | KDM4ECNR1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008367-B | It is used as the pyrrolo-triazine class compound of potassium channel inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105008367-A | Pyrrolotriazines as potassium ion channel inhibitors | BRISTOL MYERS SQUIBB CO | 2015-10-28 | — | — | CN | disclosed |