Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250182 | 0.72 | ADRB1 (0.40) | SYKLRRK2HDAC3NCOR1HDAC4 | |
| SCHEMBL1184986 | 0.72 | SYK (0.43) | SYKKDM4ELRRK2HPGDATM | |
| SCHEMBL29906009 | 0.72 | SYK (0.43) | SYKKDM4ELRRK2HPGDATM | |
| SCHEMBL28135251 | 0.71 | MEN1 (0.51) | SYKKDM4EATMHDAC4ADRB1 | |
| SCHEMBL3903500 | 0.70 | LRRK2 (0.40) | LRRK2ATML3MBTL1HDAC3NCOR1 | |
| SCHEMBL1337601 | 0.69 | ADRB1 (0.43) | SYKADRB1LOXL2 | |
| SCHEMBL3903492 | 0.68 | LRRK2 (0.37) | SYKLRRK2HDAC3NCOR1HDAC4 | |
| SCHEMBL8345900 | 0.68 | HDAC3 (0.42) | SYKKDM4ELRRK2HDAC3NCOR1 | |
| SCHEMBL28040870 | 0.68 | NOS3 (0.43) | ATML3MBTL1ADRB1GRM5MEN1 | |
| SCHEMBL15390391 | 0.66 | KMT2A (0.61) | SYKHPGDL3MBTL1HDAC3NCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085482-B | Substituted diethylenediamine compound and its application method and purposes | 广东东阳光药业有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-105085482-A | Substituted piperazine compound, and usage method and application thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-11-25 | — | — | CN | disclosed |