Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | AOC1 | P19801 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27970078 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1TDP1MEN1KDM6B | |
| SCHEMBL16485845 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1TDP1MEN1KDM6B | |
| SCHEMBL31445078 | 0.79 | GAA (0.37) | KDM4EALDH1A1TDP1MEN1KDM6B | |
| SCHEMBL23541122 | 0.77 | OPRM1 (0.41) | KDM4EALDH1A1GAAGLA | |
| SCHEMBL28040760 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL31447055 | 0.76 | HDAC4 (0.39) | GAAAKR1C1SLC22A12ABL1APP | |
| SCHEMBL31445332 | 0.75 | LPAR1 (0.36) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL23246885 | 0.73 | HDAC4 (0.40) | ALDH1A1KDM4CGAAAKR1C1SLC22A12 | |
| SCHEMBL16702740 | 0.70 | L3MBTL1 (0.43) | KDM4EALDH1A1TDP1MEN1KDM6B | |
| SCHEMBL700243 | 0.70 | AKR1C1 (0.55) | ALDH1A1MEN1KMT2AAKR1C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431419-A | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE AG | 2016-03-23 | — | — | CN | disclosed |
| CN-105408330-A | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN LA ROCHE | 2016-03-16 | — | — | CN | disclosed |