Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | RAD52 | P43351 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895500 | 0.85 | GAA (0.56) | GAAMAPTRAD52KDM4ESMN1; SMN2 | |
| SCHEMBL14266654 | 0.83 | GAA (0.61) | GAAMAPTRAD52KDM4ESMN1; SMN2 | |
| SCHEMBL519497 | 0.83 | ALDH1A1 (0.56) | GAAMAPTKDM4ESMN1; SMN2GFER | |
| SCHEMBL28954366 | 0.80 | TRIM24 (0.52) | GAAMAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6405205 | 0.79 | GAA (0.61) | GAAMAPTRAD52KDM4ESMN1; SMN2 | |
| SCHEMBL992057 | 0.79 | ALDH1A1 (0.53) | GAAMAPTKDM4ESMN1; SMN2GFER | |
| SCHEMBL3047529 | 0.79 | L3MBTL1 (0.53) | GAAMAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL2717608 | 0.77 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL4576100 | 0.77 | GAA (0.57) | GAAMAPTRAD52KDM4ESMN1; SMN2 | |
| SCHEMBL5356967 | 0.76 | ALDH1A1 (0.66) | GAAMAPTRAD52KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459258-B | Preparation and use of 1,2, 4-triazolo [1,5a ] pyridine derivatives | CEPHALON, INC. (US) | 2015-11-25 | — | — | CN | disclosed |