SCHEMBL28040845

SCHEMBL28040845

CC1=Cc2ccccc2[C]1[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.32
ACHE P22303 1/20 0.32
CDC25A P30304 2/20 0.31
CDC25B P30305 2/20 0.31
MEN1 O00255 1/20 0.31
PLIN1 O60240 1/20 0.31
NR1I2 O75469 1/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GSR P00390 1/20 0.31
TP53 P04637 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
GAA P10253 1/20 0.31
CYP2D6 P10635 1/20 0.31
MAPT P10636 1/20 0.31
HSPD1 P10809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28040414 0.83 ESR1 (0.38) LMNATSHRALOX12ACHECDC25A
SCHEMBL28040628 0.83 LMNA (0.31) LMNATSHRALOX12ACHECDC25A
SCHEMBL28040418 0.80 CDC25A (0.33) LMNAALOX12CDC25ACDC25BALDH1A1
SCHEMBL28823631 0.79 CDC25A (0.35) CDC25ACDC25BIDO1
SCHEMBL28040770 0.79 PTAFR (0.33) LMNAALDH1A1TP53MAPTMAPK1
SCHEMBL28040359 0.79 PTAFR (0.34) ALDH1A1
SCHEMBL28040823 0.78 LOXL2 (0.35) ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL28040774 0.78
SCHEMBL7270394 0.71
SCHEMBL27953351 0.70 TSHR (0.35) LMNATSHRALOX12ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed