SCHEMBL28040867

SCHEMBL28040867

Cc1ccc([SiH2]c2ccccc2)c(C)c1C

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.37
CYP1A2 P05177 2/20 0.37
CYP2A6 P11509 1/20 0.37
ACHE P22303 2/20 0.33
LMNA P02545 1/20 0.32
ALOX12 P18054 1/20 0.32
MAPT P10636 1/20 0.30
TRPA1 O75762 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL989764 0.84 TRPA1 (0.38) TSHRCYP1A2CYP2A6ACHELMNA
SCHEMBL31590141 0.83 KDM4E (0.32) TSHRACHEMAPT
SCHEMBL28823591 0.83 KDM4E (0.32) TSHRACHEMAPT
SCHEMBL28634226 0.78 TRPA1 (0.38) TSHRCYP1A2ACHELMNATRPA1
SCHEMBL988673 0.77 TSHR (0.37) TSHRCYP1A2CYP2A6ACHELMNA
SCHEMBL2453373 0.76 TSHR (0.43) TSHRCYP1A2CYP2A6ACHELMNA
SCHEMBL9319622 0.74 TDP1 (0.37) TSHRCYP1A2CYP2A6ACHELMNA
SCHEMBL28278745 0.74 TSHR (0.44) TSHRCYP2A6ACHELMNAALOX12
SCHEMBL52125 0.74 TSHR (0.44) TSHRCYP2A6ACHELMNAALOX12
SCHEMBL28040456 0.73 TSHR (0.33) TSHRACHELMNAALOX12MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed