Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375420 | 0.75 | RXFP1 (0.45) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL25274273 | 0.72 | RXFP1 (0.42) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL28041713 | 0.70 | RXFP1 (0.41) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL16935848 | 0.67 | GABRA2 (0.46) | ALDH1A1KDM4EPTGS1PTGS2ALOX15 | |
| SCHEMBL18040232 | 0.66 | RXFP1 (0.38) | RXFP1PTGS1PTGS2 | |
| SCHEMBL18040239 | 0.66 | RXFP1 (0.37) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL17979392 | 0.64 | KDM4E (0.37) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL16935797 | 0.64 | GABRA2 (0.40) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL18040241 | 0.63 | RXFP1 (0.36) | RXFP1ALDH1A1KDM4EPTGS1PTGS2 | |
| SCHEMBL1331255 | 0.63 | GRN (0.43) | ALDH1A1KDM4ELMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209467-B | Imidazopyrrolidinone derivatives and their use in the treatment of disease | 诺华股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105209467-A | Imidazopyrrolidinone derivatives and their use in the treatment of disease | NOVARTIS AG | 2015-12-30 | — | — | CN | disclosed |