Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040241 | 0.93 | RXFP1 (0.36) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL1268994 | 0.75 | WDR5 (0.36) | RXFP1PTGS1PTGS2KDM4EHCAR2 | |
| SCHEMBL25274273 | 0.71 | RXFP1 (0.42) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL375420 | 0.69 | RXFP1 (0.45) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL34469503 | 0.66 | HSD17B10 (0.38) | KDM4EHCAR2TOP2ATOP2BALDH1A1 | |
| SCHEMBL28041713 | 0.66 | RXFP1 (0.41) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL28041712 | 0.66 | RXFP1 (0.41) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL4803883 | 0.65 | HCAR2 (0.36) | KDM4EHCAR2ALDH1A1HSD17B10GAA | |
| SCHEMBL25374471 | 0.64 | HSD17B10 (0.40) | ALDH1A1CYP11B2HSD17B10GAANOTUM | |
| SCHEMBL70303 | 0.63 | SMYD3 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3064502-A1 | IMIDAZOPYRROLIDINONE COMPOUNDS | Novartis AG (CH) | 2016-09-07 | — | — | EP | disclosed |