Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040232 | 0.83 | RXFP1 (0.38) | RXFP1PTGS1PTGS2HCAR3HCAR2 | |
| SCHEMBL15903442 | 0.81 | GAA (0.37) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL13733079 | 0.79 | RXFP1 (0.39) | RXFP1PTGS1PTGS2HCAR3KDM4E | |
| SCHEMBL15142107 | 0.77 | CYP1A2 (0.46) | RXFP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14477886 | 0.75 | ALDH1A1 (0.33) | RXFP1PTGS1PTGS2HCAR3KDM4E | |
| SCHEMBL15903278 | 0.75 | HCAR2 (0.35) | RXFP1PTGS1PTGS2HCAR3KDM4E | |
| SCHEMBL375420 | 0.75 | RXFP1 (0.45) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL25274273 | 0.72 | RXFP1 (0.42) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL28041712 | 0.70 | RXFP1 (0.41) | RXFP1PTGS1PTGS2KDM4EALOX15 | |
| SCHEMBL18865608 | 0.70 | ADORA3 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209467-B | Imidazopyrrolidinone derivatives and their use in the treatment of disease | 诺华股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105209467-A | Imidazopyrrolidinone derivatives and their use in the treatment of disease | NOVARTIS AG | 2015-12-30 | — | — | CN | disclosed |