Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001010 | 0.91 | MAPT (0.67) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| Bicarbonate SCHEMBL11185192 | 0.84 | ALDH1A1 (0.58) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| Phenazine SCHEMBL6213173 | 0.77 | MAPT (0.69) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL1759326 | 0.75 | ALDH1A1 (0.72) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL382385 | 0.74 | MAPT (0.62) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL29444102 | 0.74 | MAPT (1.00) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL29450004 | 0.74 | MAPT (0.62) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL11038905 | 0.74 | MAPT (0.62) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL503252 | 0.74 | MAPT (1.00) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL42617 | 0.72 | ALDH1A1 (0.75) | ALDH1A1MAPTHSD17B10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105247348-A | Digitally enhanced microscopy for multiplexed histology | VENTANA MED SYST INC | 2016-01-13 | — | — | CN | disclosed |