Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461777 | 0.81 | KDM4E (0.37) | NPC1RAB9AGAAHDAC1HDAC8 | |
| SCHEMBL27083575 | 0.81 | RAB9A (0.38) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL17336399 | 0.81 | NPC1 (0.35) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL9938191 | 0.80 | PTGDR2 (0.33) | — | |
| SCHEMBL16208226 | 0.79 | NPC1 (0.33) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL19616132 | 0.78 | ASPH (0.41) | NPC1RAB9AMAPTNTRK1AR | |
| SCHEMBL15511586 | 0.75 | AAK1 (0.39) | NPC1RAB9AKMT2AMEN1ATR | |
| SCHEMBL15541313 | 0.74 | NPC1 (0.35) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL16702460 | 0.74 | HCAR2 (0.34) | NPC1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL19173985 | 0.72 | KCNQ3 (0.53) | NPC1RAB9AMAPTHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143200-A | Serine/threonine kinase inhibitors for the treatment of hyperproliferative|diseases | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |