Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28042337 | 0.81 | NPC1 (0.37) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL17346957 | 0.79 | GSK3B (0.40) | ATRCA1CA2 | |
| SCHEMBL21635149 | 0.77 | ABL1 (0.42) | ATRMTORABL1 | |
| SCHEMBL16208226 | 0.73 | NPC1 (0.33) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL17336616 | 0.71 | MAPT (0.58) | MAPT | |
| SCHEMBL23461777 | 0.71 | KDM4E (0.37) | NPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL15541313 | 0.71 | NPC1 (0.35) | NPC1RAB9AMAPTGAANFKB1 | |
| SCHEMBL9938191 | 0.70 | PTGDR2 (0.33) | — | |
| SCHEMBL16834154 | 0.70 | L3MBTL1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL27083575 | 0.68 | RAB9A (0.38) | NPC1RAB9AMAPTGAANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154970-B1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME (US) | 2019-11-06 | — | — | EP | disclosed |
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MERCK SHARP & DOHME CORP. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2018-03-15 | — | — | US | disclosed |
| US-9808542-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | US | disclosed |
| EP-3154970-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | Merck Sharp & Dohme Corp. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191506-A2 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MERCK SHARP & DOHME CORP. (US) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022461-B2 | Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles | MAPT, SNCA, PARK7 | NPC1 939/4885RAB9A 1163/4885MAPT 1/4885 |
| US-20170119912-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY | MAPT, SNCA, PARK7 | NPC1 1239/4885RAB9A 1065/4885MAPT 1/4885 |
| US-20180071412-A1 | PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES | MAPT, SNCA, PARK7 | NPC1 939/4885RAB9A 1163/4885MAPT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.