Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | HTR7 | P34969 | 8/20 | 0.53 |
| ▸ | HTR6 | P50406 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28152048 | 0.87 | HTR2C (0.51) | HTR1AHTR2AHTR7HTR6KMT2A | |
| SCHEMBL15756990 | 0.83 | NUDT1 (0.53) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL30885219 | 0.80 | HTR2A (0.55) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL27201256 | 0.80 | HTR2A (0.55) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL28043771 | 0.79 | HRH4 (0.62) | HRH4PTGDRALDH1A1TLR8 | |
| SCHEMBL7110415 | 0.79 | HTR1A (0.48) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL28265792 | 0.78 | HRH4 (0.51) | HTR1AHTR2ADRD2HTR7HTR6 | |
| SCHEMBL2240377 | 0.77 | GBA1 (0.47) | KMT2AMEN1POLBSLC2A1RAD52 | |
| SCHEMBL28151149 | 0.76 | HRH4 (0.64) | HRH4TLR8 | |
| SCHEMBL28152083 | 0.75 | HRH4 (0.68) | HRH4MAPTTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |