Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.34 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834938 | 0.81 | ATM (0.41) | MAPTALDH1A1SMN1; SMN2ATMTDP1 | |
| SCHEMBL27552996 | 0.81 | ALDH1A1 (0.39) | MAPTALDH1A1SMN1; SMN2TDP1HIF1A | |
| SCHEMBL28791797 | 0.81 | ITGB1 (0.45) | MAPTITGB1ITGA5ALDH1A1SMN1; SMN2 | |
| SCHEMBL28824450 | 0.81 | ATM (0.41) | MAPTITGB1ITGA5ALDH1A1ATM | |
| SCHEMBL16137955 | 0.81 | ITGB1 (0.40) | MAPTESPL1ITGB1ITGA5ALDH1A1 | |
| SCHEMBL27716643 | 0.78 | CES2 (0.37) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27570719 | 0.77 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2TDP1MEN1 | |
| SCHEMBL27696887 | 0.77 | HPGD (0.47) | MAPTALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL27700395 | 0.76 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL28043907 | 0.75 | ITGB1 (0.41) | MAPTESPL1ITGB1ITGA5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164513-A | Substituted oxo pyridine derivative and its purposes in terms of cardiovascular disorder is treated | 拜耳制药股份公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105164122-A | Substituted oxopyridine derivatives and their use in the treatment of cardiovascular disorders | Bayer Pharma AG | 2015-12-16 | — | — | CN | disclosed |