Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15757355 | 0.83 | NUDT1 (0.51) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL28151149 | 0.76 | HRH4 (0.64) | HRH4TLR8AURKAPDPK1TGFBR1 | |
| SCHEMBL28151182 | 0.75 | HRH4 (0.52) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28043771 | 0.74 | HRH4 (0.62) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28043933 | 0.73 | HRH4 (0.50) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28043714 | 0.73 | HRH4 (0.50) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28043930 | 0.73 | HRH4 (0.55) | HRH4TLR8SMN1; SMN2AURKAPDPK1 | |
| SCHEMBL28043774 | 0.72 | HRH4 (0.49) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28043806 | 0.72 | ALDH1A1 (0.52) | HRH4TLR8SMN1; SMN2ALDH1A1 | |
| SCHEMBL28845266 | 0.72 | CYP2D6 (0.55) | MEN1KMT2AGAAHRH4TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |