Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27891882 | 0.81 | HTR2A (0.37) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL27472077 | 0.81 | HTR2A (0.51) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL28678155 | 0.80 | HTR2A (0.45) | MEN1KMT2AMAPTHTR2AHTR2C | |
| SCHEMBL27908791 | 0.79 | HTR2A (0.35) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL27369292 | 0.75 | GPR84 (0.44) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL27524231 | 0.74 | NR4A2 (0.46) | PDE4DHTR2AHTR2CHTR2B | |
| SCHEMBL27771264 | 0.74 | HTR2A (0.44) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL27906752 | 0.74 | FFAR1 (0.43) | HTR2AHTR2CHTR2B | |
| SCHEMBL27965809 | 0.74 | CYP2A6 (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL27580249 | 0.74 | MEN1 (0.36) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164130-A | Dihydro-pyrrolopyridone bromodomain inhibitors | ABBVIE INC | 2015-12-16 | — | — | CN | disclosed |