Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2204635 | 0.88 | MAPT (0.53) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL309785 | 0.84 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL31129953 | 0.83 | MAPT (0.58) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL19556798 | 0.82 | MAPT (0.43) | MAPTALDH1A1LMNASMN1; SMN2PDK1 | |
| SCHEMBL15283893 | 0.82 | MAPT (0.48) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL17304018 | 0.80 | PDK1 (0.40) | MAPTALDH1A1LMNASMN1; SMN2GPR174 | |
| SCHEMBL28795237 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL28795188 | 0.79 | GPR119 (0.51) | MAPTALDH1A1LMNAGPR174 | |
| SCHEMBL25338911 | 0.79 | MAPT (0.43) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL28795204 | 0.79 | SMN1; SMN2 (0.47) | MAPTALDH1A1LMNASMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189479-A | Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds | SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD | 2015-12-23 | — | — | CN | disclosed |