Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 17/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.36 |
| ▸ | HRH1 | P35367 | 13/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279332 | 0.86 | ALOX5 (0.34) | — | |
| SCHEMBL280317 | 0.83 | AKR1C3 (0.41) | KMT2ADRD3 | |
| SCHEMBL280316 | 0.82 | HRH2 (0.39) | HRH2HRH4HRH3HRH1 | |
| SCHEMBL280462 | 0.78 | — | — | |
| SCHEMBL278857 | 0.76 | LMNA (0.48) | GAA | |
| SCHEMBL280457 | 0.74 | HRH2 (0.36) | KMT2AHRH2HRH4HRH3HRH1 | |
| SCHEMBL279977 | 0.72 | L3MBTL1 (0.39) | KMT2AGAA | |
| SCHEMBL13763088 | 0.72 | CYP1A2 (0.34) | HRH2HRH4HRH1 | |
| SCHEMBL279873 | 0.72 | ALDH1A1 (0.39) | HRH2HRH4HRH1SLC6A3GAA | |
| SCHEMBL264057 | 0.72 | PTGS1 (0.48) | KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
| US-7332513-B2 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-02-19 | — | — | US | disclosed |