Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044536 | 0.77 | HTR7 (0.33) | HTR7 | |
| SCHEMBL28044453 | 0.77 | HTR7 (0.33) | HTR7 | |
| SCHEMBL592097 | 0.76 | SIGMAR1 (0.42) | HTR7SIGMAR1CCR2ESR1ESR2 | |
| SCHEMBL589726 | 0.76 | NTSR1 (0.35) | HTR7SIGMAR1CCR2HRH3CYP2D6 | |
| SCHEMBL592328 | 0.75 | HTR7 (0.49) | HTR7SIGMAR1CCR2ESR1ESR2 | |
| SCHEMBL1355876 | 0.67 | SIGMAR1 (0.43) | SIGMAR1HRH3CYP2D6MAPK1CYP3A4 | |
| SCHEMBL11144109 | 0.66 | SIGMAR1 (0.57) | HTR7SIGMAR1CCR2HRH3 | |
| SCHEMBL1355874 | 0.66 | SIGMAR1 (0.41) | SIGMAR1CYP2D6MAPK1TP53TSHR | |
| SCHEMBL1355593 | 0.65 | SIGMAR1 (0.41) | SIGMAR1CYP2D6MAPK1CYP3A4 | |
| SCHEMBL28044442 | 0.65 | NR3C1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101594862-B | Substituted indazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-11-25 | — | — | CN | disclosed |