Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.55 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.46 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22772302 | 0.88 | TAS1R3 (0.55) | TAS1R3TAS1R1TAS1R2TRPV1HTT | |
| SCHEMBL11600879 | 0.87 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2TRPV1HTT | |
| SCHEMBL19521080 | 0.84 | KMT2A (0.54) | TAS1R3TAS1R1TAS1R2HTTMEN1 | |
| SCHEMBL20532721 | 0.84 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2TRPV1HTT | |
| SCHEMBL20532720 | 0.84 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2TRPV1HTT | |
| SCHEMBL8370042 | 0.84 | HTT (0.49) | TAS1R3TAS1R1TAS1R2HTTMEN1 | |
| SCHEMBL23362958 | 0.80 | LMNA (0.48) | TAS1R3TAS1R1TAS1R2HTTMEN1 | |
| SCHEMBL2804784 | 0.80 | TRPV1 (0.50) | TAS1R3TAS1R1TAS1R2TRPV1HTT | |
| SCHEMBL9011724 | 0.80 | HTT (0.75) | TAS1R3TAS1R1TAS1R2HTTMEN1 | |
| SCHEMBL14614701 | 0.80 | MAOA (0.52) | TAS1R3TAS1R1TAS1R2TRPV1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130296327-A1 | SUBSTITUTED HETEROCYLIC COMPOUNDS | INCYTE CORPORATION | 2013-11-07 | — | — | US | disclosed |
| US-8481732-B2 | Substituted heterocyclic compounds | INCYTE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |
| US-20100240671-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | INCYTE CORPORATION (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296327-A1 | SUBSTITUTED HETEROCYLIC COMPOUNDS | HRH4, HRH2, HRH1 | TAS1R3 981/4885TAS1R1 785/4885TAS1R2 1061/4885 |
| US-20100240671-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | HRH4, HRH2, HRH1 | TAS1R3 1418/4885TAS1R1 1511/4885TAS1R2 1502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.