Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | POR | P16435 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | PPOX | P50336 | 1/20 | 0.40 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 2/20 | 0.37 |
| ▸ | USP7 | Q93009 | 2/20 | 0.37 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229683 | 0.80 | S100A4 (0.80) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL353693 | 0.80 | S100A4 (0.80) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL16167323 | 0.79 | NQO1 (0.47) | NQO1PORPTPRCUSP8USP7 | |
| SCHEMBL29364602 | 0.77 | PTPRC (0.76) | S100A4NQO1PORPTPRCUSP8 | |
| SCHEMBL28782 | 0.77 | PTPRC (0.76) | S100A4NQO1PORPTPRCUSP8 | |
| SCHEMBL29581505 | 0.76 | S100A4 (0.71) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL4319897 | 0.76 | S100A4 (0.71) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL30345128 | 0.76 | S100A4 (0.90) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL1133148 | 0.76 | S100A4 (0.90) | S100A4HSP90AA1PPOXITGA1USP8 | |
| SCHEMBL155593 | 0.74 | S100A4 (0.87) | S100A4HSP90AA1PTPRCPPOXITGA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871802-B2 | Naphthoquinones for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2013-06-13 | — | — | US | disclosed |
| WO-2012024818-A1 | NOVEL ANPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | NQO1, NME2, CYP27B1 | S100A4 2159/4885HSP90AA1 1319/4885NQO1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.