Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 2/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17908109 | 0.84 | S1PR2 (0.32) | NAPRTSIRT6MAPKAPK2TDP1ALDH1A1 | |
| SCHEMBL4019648 | 0.83 | MAPKAPK2 (0.35) | AGBL2SIRT6MAPKAPK2TDP1ALDH1A1 | |
| SCHEMBL28797678 | 0.81 | AGBL2 (0.40) | AGBL2GABRR1GABRA1GABRA5GABRB2 | |
| SCHEMBL27870869 | 0.81 | AGBL2 (0.47) | AGBL2GABRR1GABRA1GABRA5GABRB2 | |
| SCHEMBL30529535 | 0.75 | PDXK (0.35) | MAPKAPK2KDM4EALDH1A1PDCD1CD274 | |
| SCHEMBL19641414 | 0.75 | PDXK (0.35) | MAPKAPK2KDM4EALDH1A1PDCD1CD274 | |
| SCHEMBL4520765 | 0.74 | GABRR1 (0.41) | AGBL2GABRR1AKR1B1GABRA1GABRA5 | |
| SCHEMBL12130919 | 0.73 | MAPKAPK2 (0.33) | MAPKAPK2ALDH1A1PDCD1CD274 | |
| SCHEMBL1349353 | 0.72 | MAPKAPK2 (0.36) | MAPKAPK2KDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL31373452 | 0.72 | MAPKAPK2 (0.46) | MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164121-A | Perfluorinated cyclopropyl-fused 1, 3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use thereof | AMGEN INC | 2015-12-16 | — | — | CN | disclosed |