Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048176 | 0.83 | AGBL2 (0.42) | MAPKAPK2ALDH1A1TDP1SIRT6PDCD1 | |
| SCHEMBL17908109 | 0.79 | S1PR2 (0.32) | MAPKAPK2ALDH1A1TDP1SIRT6PDCD1 | |
| SCHEMBL31373452 | 0.77 | MAPKAPK2 (0.46) | MAPKAPK2 | |
| SCHEMBL17423463 | 0.77 | MAPKAPK2 (0.46) | MAPKAPK2 | |
| SCHEMBL12130919 | 0.75 | MAPKAPK2 (0.33) | MAPKAPK2ALDH1A1PDCD1CD274 | |
| SCHEMBL17908105 | 0.75 | GRIK1 (0.36) | TDP1 | |
| SCHEMBL26046044 | 0.75 | PDE4A (0.34) | TDP1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL30529535 | 0.74 | PDXK (0.35) | MAPKAPK2ALDH1A1PDCD1CD274 | |
| SCHEMBL13259944 | 0.74 | ALDH1A1 (0.38) | MAPKAPK2ALDH1A1TDP1PDCD1CD274 | |
| SCHEMBL19641414 | 0.74 | PDXK (0.35) | MAPKAPK2ALDH1A1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |