Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 6/20 | 0.78 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.78 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomenthol SCHEMBL28048330 | 0.89 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL6238698 | 0.89 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Isomenthol SCHEMBL677675 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL12646785 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL13059620 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL9968934 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL10072505 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Racementhol SCHEMBL521946 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20771511 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL15449169 | 0.88 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-208574251-U | A kind of menthol cerium sulphate crystal equipment | 安徽银丰药业股份有限公司 | 2019-03-05 | — | — | CN | claimed |
| CN-208574251-U | A kind of menthol cerium sulphate crystal equipment | 安徽银丰药业股份有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-208574251-U | A kind of menthol cerium sulphate crystal equipment | 安徽银丰药业股份有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-208574251-U | A kind of menthol cerium sulphate crystal equipment | 安徽银丰药业股份有限公司 | 2019-03-05 | — | — | CN | disclosed |
| CN-105169741-A | Menthol crystallization control system | ANHUI YINFENG PHARMACEUTICAL CO LTD | 2015-12-23 | — | — | CN | disclosed |