Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+)-Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Isomenthol SCHEMBL677675 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Racementhol SCHEMBL521946 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL1709231 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+) Neomenthol SCHEMBL260049 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL2454317 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4540797-A | Process for resolution of chiral alcohols or phenols or chiral lactonic compounds | ROUSSEL UCLAF (FR) | 1985-09-10 | — | — | US | claimed |
| EP-0004493-B1 | ETHERS WHOSE ORGANIC MOIETIES HAVE ASYMMETRIC ATOMS, METHODS FOR THEIR PREPARATION AND THEIR USE FOR THE RESOLUTION OF ALCOHOLS, PHENOLS OR CERTAIN COMPOUNDS WITH A LACTONE STRUCTURE | ROUSSEL-UCLAF (FR) | 1981-05-06 | — | — | EP | claimed |
| US-20180169641-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-21 | — | — | US | disclosed |
| US-9988331-B2 | Method for producing optically active, racemic menthol | BASF SE (DE) | 2018-06-05 | — | — | US | disclosed |
| WO-2014125967-A1 | 3,6-O-CROSSLINKED PYRANOSE COMPOUND, AND PRODUCTION METHOD FOR α-O-PYRANOSIDE | 学校法人関西学院 (JP) | 2014-08-21 | — | — | WO | disclosed |
| EP-2329271-B1 | METHODS TO IDENTIFY MODULATORS | GIVAUDAN SA (CH) | 2012-06-20 | — | — | EP | disclosed |
| US-20110143376-A1 | Methods to Identify Modulators | GIVAUDAN SA (CH) | 2011-06-16 | — | — | US | disclosed |
| US-20100303935-A1 | Medicinal Composition | MCGINLEY PARTNERS, LLC (US) | 2010-12-02 | — | — | US | disclosed |
| WO-2010022529-A1 | METHODS TO IDENTIFY MODULATORS | GIVAUDAN SA (CH) | 2010-03-04 | — | — | WO | disclosed |
| US-4720556-A | 3-oxabicyclo-(3,1,0)-hexan-2-ones | ROUSSEL UCLAF (FR) | 1988-01-19 | — | — | US | disclosed |
| US-4658043-A | Ethers of pantolactone | ROUSSEL UCLAF (FR) | 1987-04-14 | — | — | US | disclosed |
| US-4540797-A | Process for resolution of chiral alcohols or phenols or chiral lactonic compounds | ROUSSEL UCLAF (FR) | 1985-09-10 | — | — | US | disclosed |
| US-4374257-A | Novel ethers containing a lactone group and a chiral atom | ROUSSEL UCLAF (FR) | 1983-02-15 | — | — | US | disclosed |
| US-4265817-A | Novel chiral ethers and their use in resolution of alcohols and phenols | ROUSSEL UCLAF (FR) | 1981-05-05 | — | — | US | disclosed |
| EP-0004493-A1 | Ethers whose organic moieties have asymmetric atoms, methods for their preparation and their use for the resolution of alcohols, phenols or certain compounds with a lactone structure | ROUSSEL-UCLAF (FR) | 1979-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169641-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | BRD4, NQO1, NQO2 | TRPM8 2221/4885TRPA1 1214/4885EPHX1 1734/4885 |
| US-20100303935-A1 | Medicinal Composition | MUSK, TNNC1, ACHE | TRPM8 316/4885TRPA1 143/4885EPHX1 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.