Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isomenthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Racementhol SCHEMBL521946 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL9968934 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL1709231 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+) Neomenthol SCHEMBL260049 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL2454317 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4717088-A1 | METHOD FOR IMPROVING THE CULTIVATION OF PLANTS UNDER ABIOTIC STRESS CONDITIONS | Timac Agro España, S.A. (ES) | 2026-04-01 | — | — | EP | claimed |
| WO-2025027218-A1 | METHOD FOR IMPROVING THE CULTIVATION OF PLANTS UNDER ABIOTIC STRESS CONDITIONS | TIMAC AGRO ESPAÑA, S.A., (ES) | 2025-02-06 | — | — | WO | claimed |
| CN-115515555-A | Mint flavor composition | 宝洁公司 | 2022-12-23 | — | — | CN | claimed |
| WO-2022072394-A1 | CURABLE COATING COMPOSITIONS AND ANTIMICROBIAL/ANTIVIRAL COATINGS MADE BY CURING SUCH COATING COMPOSITIONS | GREEN THEME TECHNOLOGIES, INC. (US) | 2022-04-07 | — | — | WO | claimed |
| EP-4543230-A1 | AEROSOLISABLE FORMULATION | Nicoventures Trading Limited (GB) | 2025-04-30 | — | — | EP | disclosed |
| WO-2025027218-A1 | METHOD FOR IMPROVING THE CULTIVATION OF PLANTS UNDER ABIOTIC STRESS CONDITIONS | TIMAC AGRO ESPAÑA, S.A., (ES) | 2025-02-06 | — | — | WO | disclosed |
| CN-119173243-A | Dental instrument cleaner | 赫力昂英国知识产权有限公司 | 2024-12-20 | — | — | CN | disclosed |
| CN-118985880-A | Double-crosslinked structured emulsion gel and preparation method and application thereof | 西北农林科技大学 | 2024-11-22 | — | — | CN | disclosed |
| CN-115279878-B | Cleaning composition | 联合利华知识产权控股有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-115209731-B | Cleaning composition | 联合利华知识产权控股有限公司 | 2024-07-02 | — | — | CN | disclosed |
| EP-4367211-A1 | A COMPOSITION FOR REDUCING MALODOUR | Unilever IP Holdings B.V. (NL) | 2024-05-15 | — | — | EP | disclosed |
| EP-4367210-A1 | A COMPOSITION FOR REDUCING MALODOUR | Unilever IP Holdings B.V. (NL) | 2024-05-15 | — | — | EP | disclosed |
| WO-2008138162-A1 | COMPOSITIONS AND THEIR USE | GIVAUDAN SA (CH) | 2008-11-20 | — | — | WO | disclosed |
| US-20080253973-A1 | SENSATION MODIFYING TOPICAL COMPOSITION FOAM | FOAMIX LTD. (IL) | 2008-10-16 | — | — | US | disclosed |
| US-20080255391-A1 | Chiral Phosphorus Compounds | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND (IE) | 2008-10-16 | — | — | US | disclosed |
| US-20080255391-A1 | Chiral Phosphorus Compounds | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND (IE) | 2008-10-16 | — | — | US | disclosed |
| US-20080085247-A1 | Composition of Menthyl Lactate and a Mixture of Menthol Isomers | SYMRISE GMBH & CO. KG (DE) | 2008-04-10 | — | — | US | disclosed |
| US-20080085247-A1 | Composition of Menthyl Lactate and a Mixture of Menthol Isomers | SYMRISE GMBH & CO. KG (DE) | 2008-04-10 | — | — | US | disclosed |
| US-20080038300-A1 | Self-Adhesive Skin Patch and Combination Set for Cosmetic Skin Care | BEIERSDORF AG (DE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007115593-A1 | COMPOSITION OF MENTHYL LACTATE AND A MIXTURE OF MENTHOL ISOMERS | SYMRISE GMBH & CO. KG (DE) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080038300-A1 | Self-Adhesive Skin Patch and Combination Set for Cosmetic Skin Care | CUTA, CTCF, LAGE3 | TRPM8 3469/4885TRPA1 862/4885EPHX1 4176/4885 |
| US-20080085247-A1 | Composition of Menthyl Lactate and a Mixture of Menthol Isomers | LDHA, LDHB, MDH2 | TRPM8 677/4885TRPA1 3685/4885EPHX1 2318/4885 |
| US-20080253973-A1 | SENSATION MODIFYING TOPICAL COMPOSITION FOAM | TRPA1, GPR35, TRPV1 | TRPM8 6/4885TRPA1 1/4885EPHX1 1201/4885 |
| US-20080255391-A1 | Chiral Phosphorus Compounds | PHOSPHO1, PNKP, PTMS | TRPM8 3854/4885TRPA1 756/4885EPHX1 1152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.