SCHEMBL28048520

SCHEMBL28048520

CCn1c(C(=O)O)ccc(C#N)c1=S

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.42
HPGD P15428 2/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 3/20 0.36
GPR35 Q9HC97 1/20 0.36
KMT2A Q03164 1/20 0.35
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1666276 0.69 KDM4E (0.47) L3MBTL1HPGDKDM4EALDH1A1GPR35
SCHEMBL8087890 0.65 KDM4E (0.59) L3MBTL1HPGDKDM4EALDH1A1KMT2A
SCHEMBL7958147 0.63 NTRK1 (0.57) GPR35
SCHEMBL10022666 0.63 CCR9 (0.65) ALDH1A1GPR35
SCHEMBL17477638 0.62 GPR35 (0.41) HPGDKDM4EALDH1A1GPR35KMT2A
SCHEMBL2941221 0.62 KDM4E (0.41) L3MBTL1HPGDKDM4EALDH1A1
SCHEMBL4828827 0.60 ALDH1A1 (0.56) HPGDALDH1A1KMT2A
SCHEMBL18921488 0.60 PGR (0.47)
SCHEMBL12163032 0.60 KDM4E (0.50) L3MBTL1HPGDKDM4EALDH1A1KMT2A
SCHEMBL8330002 0.59 GPR35 (0.53) HPGDKDM4EALDH1A1GPR35KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104013623-B Cyano-pyridin compounds is preparing the application in anti-HIV-1 virus drugs Guangzhou Zhongheng Electronic Technology Co.,Ltd. (CN) 2016-01-20 CN disclosed