Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957913 | 0.75 | GPR35 (0.50) | GPR35POLBKDM4EPKMALDH1A1 | |
| SCHEMBL11559372 | 0.75 | POLB (0.43) | POLBKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL1919417 | 0.72 | GPR35 (0.47) | GPR35KDM4ECCR2KMT2A | |
| SCHEMBL10693316 | 0.72 | POLB (0.37) | GPR35POLBKDM4EPKMALDH1A1 | |
| SCHEMBL30067600 | 0.70 | CCR2 (0.69) | GPR35POLBALDH1A1TSHRCCR2 | |
| SCHEMBL701976 | 0.70 | CCR2 (0.69) | GPR35POLBALDH1A1TSHRCCR2 | |
| SCHEMBL14702784 | 0.70 | GPR35 (1.00) | GPR35POLBKDM4EPKMSRC | |
| SCHEMBL17477638 | 0.69 | GPR35 (0.41) | GPR35POLBKDM4EPKMALDH1A1 | |
| SCHEMBL31094809 | 0.69 | GPR35 (0.45) | GPR35POLBKDM4EPKMSRC | |
| SCHEMBL1006638 | 0.69 | GPR35 (0.44) | GPR35POLBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |