Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 9/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31301427 | 0.85 | KMO (0.71) | MEN1KMT2AKMOSMN1; SMN2 | |
| SCHEMBL28048743 | 0.85 | KMO (0.71) | MEN1KMT2AKMOSMN1; SMN2 | |
| SCHEMBL28048742 | 0.83 | KMO (0.55) | MEN1KMT2AKMOMAP4K4SMN1; SMN2 | |
| SCHEMBL3183738 | 0.83 | MAPK8 (0.55) | MEN1KMT2AKMOMAP4K4KDM4E | |
| SCHEMBL3454018 | 0.83 | KMO (0.51) | MEN1KMT2AKMOMAP4K4KDM4E | |
| SCHEMBL3721991 | 0.80 | KMO (0.53) | KMT2AKMOMAP4K4IKBKB | |
| SCHEMBL3133736 | 0.79 | MAPT (0.52) | MEN1KMT2AKMOSMN1; SMN2ALDH1A1 | |
| SCHEMBL30661019 | 0.78 | KMO (0.46) | MEN1KMT2AKMOSMN1; SMN2 | |
| SCHEMBL31301465 | 0.77 | HSD17B1 (0.49) | MEN1KMT2AKMOSMN1; SMN2KDM4E | |
| SCHEMBL3125837 | 0.76 | SCN9A (0.55) | MEN1KMT2AL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153026-A | Biaryl amide structure containing sorafenib derivative as well as preparation method and applications thereof | UNIV JIANGXI NORMAL SCI & TECH | 2015-12-16 | — | — | CN | disclosed |