Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 13/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31301427 | 0.85 | KMO (0.71) | KMOMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28048743 | 0.85 | KMO (0.71) | KMOMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28048792 | 0.83 | MEN1 (0.53) | KMOMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27986399 | 0.83 | KMO (0.58) | KMOMEN1KMT2A | |
| SCHEMBL31301465 | 0.77 | HSD17B1 (0.49) | KMOMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL31301616 | 0.75 | KMO (0.57) | KMOMEN1KMT2ASMN1; SMN2PIK3CG | |
| SCHEMBL31301472 | 0.75 | KMO (0.57) | KMOMEN1KMT2ASMN1; SMN2PIK3CG | |
| SCHEMBL444442 | 0.73 | KMT2A (0.56) | KMOMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6508869 | 0.72 | MEN1 (0.82) | MEN1KMT2ASMN1; SMN2KDM4EPRNP | |
| SCHEMBL10194257 | 0.72 | KDM4E (0.62) | MEN1KMT2ASMN1; SMN2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732616-B | Pyrrolopyridines of the amide structure containing biaryl and its preparation method and application | 江西科技师范大学 | 2018-07-27 | — | — | CN | disclosed |
| CN-105153026-B | Sorafenib derivative of the amide structure containing biaryl and its preparation method and application | 江西科技师范大学 | 2018-02-02 | — | — | CN | disclosed |
| CN-105732616-A | Pyrrolopyridine compounds containing biaryl amide structure, preparation method and applications thereof | 江西科技师范大学 | 2016-07-06 | — | — | CN | disclosed |
| CN-105153026-A | Biaryl amide structure containing sorafenib derivative as well as preparation method and applications thereof | UNIV JIANGXI NORMAL SCI & TECH | 2015-12-16 | — | — | CN | disclosed |