Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049926 | 0.75 | PTGS2 (0.43) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL16228971 | 0.73 | PTGS2 (0.50) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL16228972 | 0.73 | PTGS2 (0.50) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL28949611 | 0.73 | KDM4E (0.57) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL30159699 | 0.71 | DAO (0.53) | KDRDAONOTUMPDE2A | |
| SCHEMBL14718624 | 0.71 | DAO (0.53) | KDRDAONOTUMPDE2A | |
| SCHEMBL28825766 | 0.70 | PTGS2 (0.43) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL28050047 | 0.68 | DAO (0.43) | MMP9PTGS2MAPTAPPPRKCE | |
| SCHEMBL3560692 | 0.67 | IAPP (0.51) | APPKDM4EPOLBGAACYP1A2 | |
| SCHEMBL3560696 | 0.67 | IAPP (0.51) | APPKDM4EPOLBGAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103748079-B | Pyridazinone mixture and the purposes as DAAO inhibitor thereof | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-03-16 | — | — | CN | disclosed |