Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825766 | 0.86 | PTGS2 (0.43) | DAOPTGS2NPC1DRD1MMP9 | |
| SCHEMBL28949611 | 0.78 | KDM4E (0.57) | DAOPTGS2PTGS1MEN1NPC1 | |
| SCHEMBL28049926 | 0.72 | PTGS2 (0.43) | PTGS2NPC1MMP9APPALOX5 | |
| SCHEMBL14718917 | 0.71 | DAO (0.54) | DAO | |
| SCHEMBL11467195 | 0.70 | FOS (0.54) | PTGS2PTGS1MEN1NPC1KMT2A | |
| SCHEMBL11467196 | 0.70 | FOS (0.54) | PTGS2PTGS1MEN1NPC1KMT2A | |
| SCHEMBL16228972 | 0.70 | PTGS2 (0.50) | DAOPTGS2PTGS1NPC1MMP9 | |
| SCHEMBL16228971 | 0.70 | PTGS2 (0.50) | DAOPTGS2PTGS1NPC1MMP9 | |
| SCHEMBL1536624 | 0.69 | ALDH1A1 (0.61) | PTGS2PTGS1MEN1AGTR1KMT2A | |
| SCHEMBL1536621 | 0.69 | ALDH1A1 (0.61) | PTGS2PTGS1MEN1AGTR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103748079-B | Pyridazinone mixture and the purposes as DAAO inhibitor thereof | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-03-16 | — | — | CN | disclosed |