Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825832 | 0.82 | MPO (0.42) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL18725397 | 0.74 | NOTUM (0.49) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL7465412 | 0.73 | CALM1 (0.41) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27803014 | 0.73 | KDM4E (0.44) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL4878068 | 0.72 | NOTUM (0.44) | NOTUMKDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL41608 | 0.71 | NOTUM (0.59) | NOTUMDRD2DRD4DRD3CHRM1 | |
| SCHEMBL28181607 | 0.70 | NOTUM (0.59) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL711055 | 0.70 | NOTUM (0.63) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL28923071 | 0.70 | KDM4E (0.46) | NOTUMDRD2DRD4DRD3MPO | |
| SCHEMBL1032919 | 0.69 | NOTUM (0.53) | NOTUMDRD2DRD4DRD3MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829294-A | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | 詹森药业有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105209453-A | Methylene linked quinolinyl modulators of ROR-gamma-T | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |